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Association Between Peri-Transfer Endometrial Peristalsis And Live Birth In Modified Natural Cycle Frozen Embryo Transfer: A Prospective Cohort Study

Recruitingn/aAges 18 Years - 42 YearsFemaleMแปน ฤแปฉc Hospital
NCT07358468 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

The uterus is a dynamic muscular organ that undergoes rhythmic, wave-like contractions known as endometrial peristalsis or endometrial waves. This muscular activity, which is an essential component of natural fertility, presents a nuanced and sometimes contradictory role in the context of assisted reproductive treatments. Endometrial peristalsis refers to the frequency, amplitude, and pattern of myometrial contractions occurring in different reproductive phases. These peristalsis play vital roles in sperm transport, embryo migration, and implantation. Clinical and imaging studies suggest that abnormal patterns or excessive contractility at the time of embryo transfer may disrupt endometrial-embryo synchrony, impair implantation, and increase miscarriage risk. However, most evidence on endometrial peristalsis pertains to fresh embryo transfer cycles, natural conceptions, or pathological c

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Women aged 18 - 42 years old * Scheduled for frozen embryo transfer cycles using hormone replacement therapy protocol or natural cycle protocol (True natural cycles or modified natural cycles) * Transferred no more than two cleavage embryos or one good-quality blastocyst or no more than two poor-quality blastocysts Exclusion Criteria: * Having an allergy and contraindications for exogenous hormone administration (e.g., breast cancer, thromboembolic disease) * Cycles with preimplantation genetic testing, oocyte donation, or in vitro maturation * Having untreated uterine or adnexal abnormalities (e.g., intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus, endometrial polyp, large leiomyoma โ‰ฅ5 cm in diameter, hydrosalpinx, endometrial hyperplasia). * Use of uterine relaxants or intralipid infusion during the embryo transfer process. * Use of a GnRH-agonist for downregulation within one month. * PCOS patients
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What it tests

  • Endometrial peristalsis and hormone measurements
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Where

2 sites
My Duc Phu Nhuan Hospital
Ho Chi Minh City, Vietnam
IVFMD Phu Nhuan - My Duc Phu Nhuan Hospital
Ho Chi Minh City, Vietnam
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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