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The Relationship Between Serum S100B and Brain-Derived Neurotrophic Factor

Recruitingn/aAges 18 Years - 50 YearsFemaleKanuni Sultan Suleyman Training and Research Hosp…
NCT07358754 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Fibromyalgia is a chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive symptoms. Central sensitization is considered a key mechanism in the pathophysiology of fibromyalgia; however, the underlying biological markers have not been fully clarified. Brain-derived neurotrophic factor (BDNF) and S100B protein have been suggested to play roles in neuroinflammation and central pain processing. This observational, cross-sectional study aims to evaluate serum S100B and BDNF levels in patients with fibromyalgia and to investigate their relationship with central sensitization and sleep quality. Serum biomarker levels and clinical assessment scales will be compared between patients with fibromyalgia and healthy controls.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female participants aged between 18 and 50 years Diagnosis of fibromyalgia according to 2016 American College of Rheumatology (ACR) criteria Symptoms present for at least 3 months Ability to understand and complete study questionnaires Provision of written informed consent For healthy controls: No diagnosis of fibromyalgia or chronic widespread pain No known systemic disease Exclusion Criteria: \-
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What it tests

  • No Intervention (Observational Study)
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Where

1 site
Kanuni Sultan Süleyman Training and Research Hospital
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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