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Comparison of Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous PCA Following Mixed Surgery

RecruitingNAAges 18 Years - 65 YearsAllBeijing Tiantan Hospital
NCT07361822 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Perioperative pain management affects patient recovery. However, the rate of moderate to severe postoperative pain is as high as 73.8%, which hinders recovery and increases the risk of complications. Although opioids are the first-line analgesics, excessive use leads to adverse reactions. The traditional fixed-rate PCA mode is difficult to match the changes in postoperative pain. This study will compare different PCA mode optimization strategies, assuming that they can reduce opioid dosage, improve analgesic effect, and reduce adverse reactions, providing high-quality evidence-based basis for postoperative analgesia and promoting individualized and intelligent management.

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📋 Eligibility rules (as published)
Inclusion Criteria: * aged between 18 to 65 years; * American Society of Anesthesiologists physical status Ⅰ - Ⅲ; * Patients scheduled for elective mixed surgery were enrolled. Mixed surgeries included thoracic, abdominal, spinal, orthopaedic, and cranial procedures performed using either minimally invasive or open approaches. Exclusion Criteria: * Allergy to PCA medications; * Presence of chronic pain syndromes; * Presence of psychiatric disorders, or severe cardiovascular, cerebrovascular, renal, or hepatic dysfunction.
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What it tests

  • Fixed-rate basal infusion mode
  • Variable-rate feedback infusion mode
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Where

1 site
Beijing Tiantan Hospital, Beijing, Beijing 100070
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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