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Trial of an AI-enabled Digital Stethoscope to Improve Antibiotic Stewardship

RecruitingPhase 4Ages 2 Months - 59 MonthsAllJohns Hopkins University
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In plain words

What the trial is, and whether it could suit you

Antibiotics are a mainstay of the treatment of lower respiratory infections in young children even though most episodes are caused by self-limiting viruses. Innovative child friendly tools that improve the diagnosis of respiratory illnesses, safely reduce the unnecessary use of antibiotics, and are suitable for implementation in resource-constrained settings are urgently required to safely improve antibiotic stewardship and stem the rising rates of antibiotic resistance globally. In the Bangladesh Lung Auscultation Artificial Intelligence for Antibiotic Stewardship Trial (BLAAAST) the investigators aim to determine whether treatment failure frequency among children in rural Bangladesh managed by clinical guidelines enhanced by a commercially available, artificial intelligence (AI)-enabled digital stethoscope is non-inferior to guidelines alone. The investigators hypothesize treatment fa

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * 2 to 59 months of age (60 days to 59 months 29 days), * illness duration 14 days or less, * meeting non-severe pneumonia criteria, and * from the trial catchment areas. Exclusion Criteria: * prior participation, * age \<2 months or \>59 months, * illness duration \>14 days, * not meeting IMCI-defined non-severe pneumonia criteria, * oxygen saturation (SpO2) \<90%, * moderate or severe malnutrition, * known chronic disease, * history of prematurity, * one or more high risk clinical signs (any WHO-defined clinical danger sign and/or WHO-defined emergency sign), * known antibiotic exposure in the past 1 week, * non-respiratory illness requiring systemic antibiotic treatment according to IMCI guidelines.
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What it tests

  • Automated digital stethoscope
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Where

1 site
Projahnnmo Research Foundation
Sylhet, Bangladesh
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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