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Interaction Between Intraventricular Flow and Cardiac Mechanics Using 3D Echocardiography in Athletes and Sedentary Subjects

Recruitingn/aAges 18 Years - 45 YearsAllUniversity of Avignon
NCT07363993 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Exercise-induced cardiac remodeling, known as the "athlete's heart," corresponds to morphological and functional adaptations of the left ventricle in response to prolonged physical training. It is characterized in particular by physiological hypertrophy and improved myocardial function. Intraventricular blood flow interacts with cardiac mechanics. Regional shape (e.g., sphericity, wall curvature) and myocardial deformations guide flow patterns to create an optimal hemodynamic environment. The interaction between these different parameters in the athlete's heart remains insufficiently explored. In this context, 3D echocardiography makes it possible to combine indices derived from fluid dynamics, regional myocardial function, and cardiac geometry, enabling a comprehensive assessment of cardiac performance. Primary and secondary objectives: In this context, the aim of this project is to

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📋 Eligibility rules (as published)
Inclusion criteria for athletes: \- Athlete practicing at least 10 hours of endurance training per week for a minimum of 5 years. Inclusion criteria for controls: \- Individual not training in more than 3 hours of physical activity per week. Exclusion Criteria for both groups: * History of known heart disease; * Current cardiac rhythm disorder; * Individual with one or more cardiovascular risk factors (smoking, diabetes, hypertension, body mass index \> 30 kg/m²); * Individual in a period of relative exclusion in relation to another protocol, or for whom the annual maximum compensation amount of €4,500 has been reached; * Individual not affiliated with a social security system, or not benefiting from such a system; * Pregnant or breastfeeding woman; patient unable to give informed consent; protected adults; vulnerable persons; * Individual deprived of liberty by judicial or administrative decision. Exclusion criteria for athletes: \- Use of substances listed on the prohibited substances list of the French Anti-Doping Agency
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What it tests

  • Not listed
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Where

2 sites
LaPEC
Avignon, France
CHU Montpellier
Montpellier, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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