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Cognitive Function in Obstructive Sleep Apnea

Recruitingn/aAges 18 Years - 65 YearsAllComenius University
NCT07364318 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder and has been increasingly recognized as a contributor to cognitive decline and a potential risk factor for neurodegeneration. Previous studies have identified several associated comorbidities, including vascular dysfunction, metabolic alterations, and neuroinflammatory changes. However, the impact and underlying interplay of these pathophysiological mechanisms remain poorly understood due to the lack of integrated, multidimensional assessment. This prospective, observational, longitudinal cohort study aims to investigate cognition and OSA-related physiological and pathophysiological processes in 100 adults newly diagnosed with OSA, who have no history of chronic diseases (except for overweight and obesity) and are not receiving chronic medication. A subgroup of patients with moderate to severe OSA indicated

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Informed consent. 2. Age 18 - 65 years. 3. Newly diagnosed OSA according to the criteria of the American Academy of Sleep Medicine Guidelines (overnight PSG with an AHI ≥5 events per hour, hypopneas defined by ≥ 10 seconds of airflow reduction accompanied by ≥ 3% desaturation or an arousal). 4. Able to accomplish relevant tests and follow-up. Exclusion Criteria: 1. History of any chronic disease other than overweight and obesity. 2. Severe psychiatric condition that could affect cognitive functions. 3. Chronic use of medication or nicotine that may affect the study results. 4. Prior neuropsychological assessment less than 6 months before the start of the research. 5. Prior therapy for OSA (i.e., CPAP, upper airway surgery, or oral appliance). 6. Motor or sensory deficits that would significantly complicate test administration. 7. Patients who do not have Slovak as their native language actively used in daily communication. 8. Considered by the study team as not suitable for enrollment based on clinical judgment.
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What it tests

  • Not listed
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Where

1 site
1st Department of Neurology, Faculty of Medicine, Comenius University and University Hospital Bratislava, Slovakia
Bratislava, Slovakia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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