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Evaluation of Internal Nasal Splint-Supported Free Graft Versus Nasoseptal Flap for Endoscopic Skull Base Repair in Cerebrospinal Fluid Leaks

RecruitingNAAges 18 Years - 70 YearsAllKafrelsheikh University
NCT07368348 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study aims to compare the feasibility and effectiveness of using an internal nasal splint- supported free graft versus a nasoseptal flap alone for endoscopic repair of bilateral CSF leaks. Research question: Does the use of an internal nasal splint to support a free graft during endoscopic repair of bilateral CSF leaks improve outcomes compared to the use of a nasoseptal flap alone?

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📋 Eligibility rules (as published)
Inclusion Criteria: 1- Adults (≥18 years). 2- Patients with bilateral CSF leaks confirmed by imaging and biochemical testing (e.g., beta-2 transferrin). 3- Patients with bilateral CSF leak and sever septal spur. 4- Patients with bilateral CSF leak and history of submucosal resection of nasal septum. 5- Patients with bilateral CSF leak and large septal perforation. 6- Patients with bilateral CSF Leak and septal granuloma. Exclusion Criteria: 1- Patients with contraindications to endoscopic surgery. 2- Active sinus or nasal infections. 3- Previous nasal or skull base surgery affecting the repair site. \-
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What it tests

  • Internal Nasal Splint-Supported Free Graft
  • Nasoseptal Flap for Endoscopic Skull Base Repair in Cerebrospinal Fluid Leaks
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Where

1 site
Kafrelsheikh Faculty of Medicine
Kafr Elsheikh, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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