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Immersive AOT: Multisensory Stimulation and Neurophysiological Correlates in Children With Cerebral Palsy and Typical Development - A Pilot Study

Recruitingn/aAges 7 Years - 25 YearsAllIRCCS Fondazione Stella Maris
NCT07369193 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The discovery of the Mirror Neuron System (MNS) has promoted the development of rehabilitation techniques such as Action Observation Treatment (AOT) and Motor Imagery (MI). These are based on the principle that neural circuits active during execution, also activate during the observation or imagination of movements. These techniques have been found to be effective in several clinical populations including children with Cerebral Palsy (CP), the most common childhood-onset motor disorder. We hypothesize that a multimodal version of AOT, integrating not only visual stimuli (standard practice) but also auditory and tactile stimuli, could further enhance the activation of the MNS. In fact, everyday actions naturally involve multiple sensory channels, and evidence indicate that audio-visual action observation activates the MNS more intensely than visual stimuli alone, thus offering a potential

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📋 Eligibility rules (as published)
Study Group: Inclusion Criteria: * Confirmed diagnosis of cerebral palsy, documented by clinical history and instrumental examinations; * Age between 7 and 25 years at the time of recruitment; * At least one verbal or nonverbal intellectual functioning index \>= 70, to ensure understanding and compliance with the tasks required. Exclusion Criteria: * Severe sensory disorders that compromise the feasibility of the study; * Neuropsychiatric comorbidity that precludes participation in the study. Control group: Inclusion Criteria * Age between 7 and 25 years at the time of recruitment; * Absence of intellectual disability, assessed through age-appropriate versions of the Raven's Progressive Matrices (Coloured Progressive Matrices for children up to 11 years; Standard Progressive Matrices for participants aged 12 years and older), yielding scores within the normative range and used to estimate non-verbal fluid intelligence; * Age-appropriate academic performance with no reports of significant learning difficulties, as verified through parental interview; * Absence of known neurological or psychiatric disorders, confirmed through parental interview; * Absence of motor impairments, defined as scoring above the 25th percentile on the Movement Assessment Battery for Children, Second Edition (MABC-2).
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What it tests

  • Not listed
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Where

1 site
IRCCS Fondazione Stella Maris
Calambrone, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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