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Repetitive Transcranial Magnetic Stimulation for Motor Recovery After Ischemic Stroke (rTMS-MOTOR)

RecruitingNAAges 18 Years - 80 YearsAllHanoi Medical University
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In plain words

What the trial is, and whether it could suit you

Ischemic stroke is a leading cause of long-term motor disability, frequently resulting in hemiplegia and limitations in daily activities and quality of life. Motor rehabilitation is a fundamental component of post-stroke care across all stages of recovery; however, functional outcomes may vary, particularly in patients with persistent motor impairment. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that has been used as an adjunct to rehabilitation to modulate cortical excitability and potentially support motor recovery. The purpose of this study is to evaluate the effects of low-frequency rTMS combined with conventional motor rehabilitation compared with sham rTMS combined with conventional motor rehabilitation in patients with first-ever ischemic stroke during the acute, subacute, and chronic stages. Motor function, balance, function

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Aged 18 to 80 years. * Diagnosed with a first-ever ischemic stroke, confirmed by neuroimaging. * Presence of unilateral hemiparesis attributable to the first-ever ischemic stroke. * Time since stroke onset: * Acute stage: \< 1 month after stroke onset * Subacute stage: 1 to 6 months after stroke onset * Chronic stage: \> 6 months after stroke onset * Moderate neurological impairment, defined as a baseline NIHSS score between 5 and 14. * Cognitive ability sufficient to understand and follow instructions, indicated by a baseline MMSE score โ‰ฅ 20. * Medically stable and able to participate in a structured motor rehabilitation program. * Provided written informed consent prior to study enrollment. * NIHSS and MMSE scores are assessed at baseline only to characterize neurological severity and cognitive status at study entry Exclusion Criteria: * Motor impairment caused by conditions other than ischemic stroke, such as musculoskeletal disorders, traumatic brain injury, Parkinson's disease, encephalitis, or other neurological conditions. * Contraindications to repetitive transcranial magnetic stimulation, including but not limited to intracranial metallic implants, implanted electronic medical devices (e.g., pacemaker), cochlear implants, known bleeding disorders, pregnancy, history of epilepsy or seizure disorders, severe cardiac disease, severe psychiatric or neurological disorders interfering with participation, or active skin conditions at the stimulation site. * History of epilepsy or seizure disorders. * Recurrent stroke occurring during the intervention period. * Refusal to participate, withdrawal of informed consent, or non-adherence to the intervention protocol.
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What it tests

  • Active repetitive transcranial magnetic stimulation
  • Sham repetitive transcranial magnetic stimulation
  • Conventional motor rehabilitation
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Where

1 site
Hanoi Rehabilitation Hospital
Hanoi, Vietnam
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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