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Cerclage Plus Progesterone vs Progesterone Alone in Twin Short Cervix

RecruitingNAAges 18 Years - anyFemaleNational Hospital of Obstetrics and Gynecology
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In plain words

What the trial is, and whether it could suit you

This study aims to compare the effectiveness of cervical cerclage combined with progesterone versus progesterone alone in preventing preterm birth among women with twin pregnancies and a short cervix (cervical length ≤ 30 mm). Participants will be randomly allocated to either the intervention group (cerclage plus progesterone) or the control group (progesterone alone).

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Maternal age ≥ 18 * Twin pregnancy * Asymptomatic short cervix (CL≤30mm) at routine ultrasound investigation * Gestational age at 16+0- 24+0 weeks Exclusion Criteria: A potential paticipant who meets any of the following criteria will be excluded from participation in this trial: * Women with twin pregnancy in which one or both fetuses are diagnosed with a major structural or congenital abnormality that is likely to influence the composite adverse neonatal outcome. * Women with a monochorionic monoamniotic twin pregnancy * A monochorionic twin pregnancy with twin-to-twin transfusion syndrome before or at the time of inclusion. * Patients have indications for vaginal cerclage: Recurrent late miscarriage (from 14 weeks) or preterm birth occurring two or more times. * Women with dilatation of the cervix diagnosed by ultrasound or physical exam * Women with overt symptoms of preterm labor at the time of measurement of the short cervix (regular contractions, PPROM, recurrent blood loss). * Women with the presence of fever ≥ 38 degrees Celsius. * Women with a placenta previa, vasa previa. * Uterine malformations: unicornuate uterus, bicornuate uterus, uterine septum, fibroid… * Severe maternal conditions (heart failure, chronic kidney disease, systemic lupus erythematosus …)
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What it tests

  • Cervical cerclage
  • Progesterone
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Where

6 sites
Bac Ninh 1 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam
Bac Ninh, Vietnam
Bac Ninh 2 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam
Bac Ninh, Vietnam
National Hospital of Obstetrics and Gynecology
Hanoi, Vietnam
Hung Yen Obstetrics and Pediatrics Hospital, Hung Yen, Vietnam
Hung Yen, Vietnam
Ninh Binh Obstetrics and Pediatrics Hospital, Ninh Binh, Vietnam
Ninh Bình, Vietnam
Quang Ninh Obstetrics and Pediatrics Hospital, Quang Ninh, Vietnam
Quang Ninh, Vietnam
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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