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Clostridioides Difficile: Understanding Responses and Treatment Effects

Recruitingn/aAges 18 Years - anyAllUmeå University
NCT07374094 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to learn how different treatments for Clostridioides difficile infection (CDI) work, and which biological mechanisms are involved in recovery. The study will compare standard antibiotic treatment and fecal microbiota transplantation (FMT). The main questions it aims to answer are: * How do antibiotic treatment and FMT affect treatment outcome in CDI? * How does the gut microbiota change during and after treatment? * Which microbial and metabolic factors are associated with recovery or treatment failure? * How does treatment affect the intestinal barrier, immune response, and patient-reported quality of life? Participants with CDI will receive treatment as part of routine clinical care, either antibiotics or FMT. Researchers will follow participants over time and collect biological samples to study treatment effects. Participants will: * Provid

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18 years or older * Symptomatic, microbiologically verified Clostridioides difficile infection * Receiving inpatient or outpatient care at Umeå University Hospital * Able and willing to provide written informed consent * Willing to participate in protocol-driven follow-up for up to 5 years Exclusion Criteria: * Age below 18 years * Inability to provide written informed consent
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What it tests

  • Antibiotic treatment
  • Fecal microbiota transplantation (FMT)
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Where

1 site
Umeå University Hospital
Umeå, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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