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Metabolomics of Cancers of the Upper Aerodigestive Tract

Recruitingn/aAges 18 Years - anyAllCentre Antoine Lacassagne
NCT07377084 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Metabolomics, thanks to advances in mass spectrometry, allows for the analysis of cellular metabolites to better understand biological processes. In oncology, it provides a global view of metabolic alterations in tumors and enables the classification of cancers based on various medical parameters using advanced statistical methods (machine learning). Its low cost and speed make it a promising approach in personalized medicine. Cancers of the upper aerodigestive tract (UADT), the fifth most common cancer in France, are often diagnosed late, reducing survival chances (35-50% at five years). Identifying a specific metabolomic signature for these cancers could facilitate early detection, assess treatment response, and rapidly detect recurrences. Additionally, HPV-induced tumors may exhibit a distinct metabolic profile compared to those caused by tobacco and alcohol. Currently, no published

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📋 Eligibility rules (as published)
Inclusion Criteria: * Histologically proven squamous cell carcinoma of the upper aerodigestive tract (oral cavity, oropharynx, larynx, and hypopharynx), stage T1-4, N0-3, M0, untreated. * Curative treatment planned at CAL. * Patient who has voluntarily consented to the use of their data and signed a non-opposition form for the use of their biological and tumor samples. Exclusion Criteria: * Metastatic patient (M1). * No curative treatment possible. * History of cancer (other than basal cell carcinoma) in the last 5 years. * Tumor size deemed insufficient according to the assessment of the ENT surgeon. * Patient refusal to allow the use of their biological and tumor samples for research. * Vulnerable persons are defined in articles L1121-5 to -8: * Pregnant women, women in labor, and nursing mothers, individuals deprived of liberty by a judicial or administrative decision, individuals hospitalized without consent under articles L. 3212-1 and L. 3213-1 who are not covered by the provisions of article L. 1121-8, * And individuals admitted to a health or social establishment for purposes other than research, * Adults under legal protection or unable to express their non-opposition.
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What it tests

  • Blood samples for the analysis of sildenafil in plasma
  • urine samples
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Where

1 site
Centre Antoine Lacassagne
Nice, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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