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HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics

RecruitingNAAges 18 Years - anyAllErasme University Hospital
NCT07377162 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU). Many ICU patients receive more oxygen than strictly necessary, and high blood oxygen levels (hyperoxemia) are very common. However, the immediate effects of short hyperoxic exposures on cerebral circulation and autoregulation remain poorly understood. In this study, patients who already require mechanical ventilation for medical reasons will undergo a brief and controlled increase in the oxygen delivered through the ventilator (FiO₂). During this time, we will continuously monitor blood flow in one of the main brain arteries using a non-invasive ultrasound technique called transcranial Doppler (TCD). The goal is to evaluate how cerebral blood flow, pulsatility, and autoregulator

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📋 Eligibility rules (as published)
Inclusion Criteria * Adult patients aged ≥18 years * Admitted to the intensive care unit (ICU) * Intubated and mechanically ventilated for ≤72 hours * Receiving volume-controlled mechanical ventilation * Arterial partial pressure of carbon dioxide (PaCO₂) between 35 and 45 mmHg * Invasive arterial blood pressure monitoring in place * Adequate transcranial Doppler (TCD) acoustic window * Clinically judged to be suitable for a brief normobaric hyperoxic stimulus * Expected to receive one or two hyperoxic steps based on baseline FiO₂ requirements: a) Baseline FiO₂ \< 0.5: two-step hyperoxic stimulus (FiO₂ 0.5 followed by FiO₂ 1.0); b) Baseline FiO₂ ≥ 0.5: one-step hyperoxic stimulus (FiO₂ 1.0) Exclusion Criteria: * Age \<18 years * Pregnancy * Extracorporeal membrane oxygenation (ECMO) * Continuous renal replacement therapy (CRRT) * Contraindications to hyperoxia, as judged by the treating physician * Severe hemodynamic instability requiring changes in vasopressor dose during the recording period * Inability to obtain a reliable transcranial Doppler signal through the temporal acoustic windows * Any clinical condition deemed by the treating physician to pose unacceptable risk during hyperoxic exposure
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What it tests

  • Normobaric Hyperoxic Stimulus (NBHO)
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Where

1 site
Erasme Hospital - ULB
Brussels, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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