DEfeating PEnile CAncer-2

Inclusion Criteria: * 1\. Patient has provided written informed consent. * 2\. Male patient ≥ 18 years at time of signing the informed consent form. * 3\. Patient has histologically proven penile squamous cell carcinoma. * 4\. Patient has indication for prophylactic (intermediate or high-risk primary tumor and cN0) or therapeutic (cN1/2) inguinal lymphadenectomy, i.e.: * pT1a, G2, cN0 OR * pT1b- pT3, any G, cN0 OR * pTa-pT3, any G, cN1-2 * 5\. Patients has adequate hepatic, renal and bone marrow function: * Hemoglobin ≥ 8.0 g/dL * Absolute neutrophil count ≥ 1.5 x 109 /L * Platelets ≥ 100 x 109 /L * International normalized ratio (INR) / activated partial thromboplastin time (aPTT) ≤ 1.5 × ULN unless participant is receiving anticoagulant therapy as long as PTT is within therapeutic range of intended use of anticoagulants. Anticoagulation is accepted according to the surgeon's practice. * 6\. Patient is willing and able to comply with the protocol for the duration of the study, including hospital visits for treatment and scheduled follow-up visits and examinations. * 7\. Performance status of the patient is judged by the treating physician as appropriate to undergo surgery. Exclusion Criteria: * 1\. Patients has inguinal bulky disease ≥ 4 cm (determined by ultrasound or cross-sectional imaging). * 2\. Patient has distant metastases. * 3\. Patient receives or is scheduled for neoadjuvant chemotherapy for PeCa. * 4\. Patient received previous major inguinal surgery (transabdominal laparoscopic inguinal hernia repair is permitted), sentinel or other lymph node resection or radiotherapy in the groin or pelvic area. * 5\. Patient participates in competing trials affecting the effects of the surgery or outcome measures. * 6\. Patient has addictive or other medical conditions that do not allow the subject to appreciate the nature and scope of the clinical trial and its potential consequences. * 7\. Patient has any co-existing medical condition that in the investigator's judgement will substantially increase the risk associated with the patient's participation in the study. * 8\. Patient has been incarcerated or involuntarily institutionalized by court order or by the authorities. * 9\. Patient is unable to consent because he does not understand the nature, significance and implications of the clinical trial and therefore cannot form a rational intention in the light of the facts.