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VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site

Recruitingn/aAges 18 Years - anyAllCopenhagen University Hospital, Rigshospitalet
NCT07380477 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to: 1. investigate various biomarkers, with a primary focus on the development of cerebrospinal fluid lactate in relation to ventriculostomy-associated infection; 2. compare proximal and distal sample results obtained from an external ventricular drain; 3. describe the natural progression of various biomarkers in blood and cerebrospinal fluid following acute brain injury.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \>18 years * EVD in situ * Admission to the neuro-ICU or neurosurgical step-down unit at Rigshospitalet, Denmark * Diagnosis of acute brain injury categorized as traumatic brain injury, subarachnoid haemorrhage, intracranial haemorrage, intraventricular haemorrhage Exclusion Criteria: * Patient or closest relatives do not understand written and spoken Danish or English * Patients transferred to Rigshospitalet with an EVD * Patients with brain injury due to existing brain infection (e.g., meningitis, intracranial empyema or abscess, encephalitis) * Patients with existing ventriculoperitoneal or ventriculoatrial shunt at the time of admission * Patients with primary or secondary brain cancer * Patients died or in palliative care
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What it tests

  • Sampling of blood and cerebrospinal fluid
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Where

1 site
Rigshospitalet
Copenhagen, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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