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Neurorehabilitation in Patients With Disorders of Consciousness: Multidimensional Ambispective Study on the Impact of Single and Combined Approaches

Recruitingn/aAges 18 Years - 90 YearsAllIRCCS Centro Neurolesi Bonino Pulejo
NCT07385508 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Disorders of consciousness (DOC), such as the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and the minimally conscious state (MCS), represent severe clinical conditions arising from acquired brain injury (ABI), exerting a profound impact on patients, caregivers, and healthcare systems. The clinical heterogeneity, diagnostic challenges, and paucity of robust evidence on the comparative efficacy of rehabilitation interventions underscore the need for a deeper understanding of the underlying neurophysiological, cognitive, and biological mechanisms involved in consciousness recovery. This monocentric ambispective observational study aims to investigate the effects of advanced neurorehabilitation treatments-including multimodal sensory stimulation, non-invasive neuromodulation via transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS), and the

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of VS/MCS following ABI, according to clinical and neuroradiological findings. * Age between 18 and 90 years. * Adequate pulmonary gas exchange function (PaO₂ / FiO₂ ratio ≥ 250). * Stable haemodynamic profile (absence of significant arterial variations in mean arterial pressure and/or heart rate). Exclusion Criteria: * Diagnosis of DOC due to non-structural aetiopathogenesis. * Having previously undergone multiple rehabilitation cycles * Being affected by deafness and/or blindness * Having unstable intracranial pressure values * Having cerebral perfusion values below 60 mmHg * Having other concomitant medical conditions that could interfere with the rehabilitation
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What it tests

  • Multidisciplinary neurorehabilitation
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Where

1 site
IRCCS Centro Neurolesi Bonino-Pulejo
Messina, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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