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Impact of Bupivacaine Dilution With Dextrose or Saline on Infraclavicular Block Outcomes

RecruitingNAAges 18 Years - 65 YearsAllBurçin Alaçam, MD
NCT07386327 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

D5W) has long been used as an intravenous fluid for hydration and energy supplementation and has recently gained increasing clinical interest in perineural injection therapies and ultrasound-guided hydrodissection. D5W has been shown to improve pain and functional outcomes in entrapment neuropathies by mechanically releasing perineural adhesions and potentially modulating neurogenic inflammation. In contrast, 0.9% sodium chloride (normal saline) is routinely used as a dilution medium for local anesthetics in peripheral nerve blocks; however, emerging evidence suggests that alternative diluents such as D5W may influence block onset and efficacy. The infraclavicular block is a commonly used ultrasound-guided technique for brachial plexus anesthesia, providing reliable anesthesia and postoperative analgesia for upper extremity surgery. This study aims to compare the effects of diluting bup

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients who agree to participate in the study and provide written informed consent * Patients scheduled for elective upper extremity surgery for whom infraclavicular block is considered appropriate for anesthetic management * Age between 18 and 65 years * American Society of Anesthesiologists (ASA) physical status I-III * Patients with a normal neurological examination in the extremity scheduled for peripheral nerve block Exclusion Criteria: * Patients who decline to participate in the study or refuse to provide informed consent * History of allergy or hypersensitivity to study medications * Body mass index (BMI) ≥ 30 kg/m² * Body weight less than 40 kg * Age below 18 years or above 65 years * History of significant cardiac disease (e.g., arrhythmia, conduction disorders) * Presence of coagulopathy (international normalized ratio \[INR\] \> 1.5 and/or platelet count \< 100,000/mm³) * Hepatic failure or significant liver dysfunction * Pregnant patients * Infection at the planned peripheral block site * Presence of neurological deficit in the extremity planned for peripheral nerve block * Patients with uncontrolled diabetes mellitus and/or established diabetic neuropathy * American Society of Anesthesiologists (ASA) physical status IV
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What it tests

  • Blocked and analgesia time
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Where

1 site
Sakarya University-Anesthesiology and Reanimation Department
Sakarya, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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