๐ŸŒ EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA

RecruitingNAAges 65 Years - 100 YearsAllPoznan University of Medical Sciences
NCT07386600 on ClinicalTrials.gov โ†—
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

This randomized, double-blind, controlled trial is designed to compare the analgesic efficacy and safety of perineural dexamethasone versus perineural dexmedetomidine as adjuvants to ropivacaine for ultrasound-guided interspace between the popliteal artery and the capsule of the posterior knee (iPACK) and adductor canal blocks in patients undergoing primary unilateral total knee arthroplasty (TKA). Elderly participants scheduled for elective TKA will be randomized into three parallel groups: ropivacaine alone (control), ropivacaine combined with perineural dexamethasone, or ropivacaine combined with perineural dexmedetomidine. The primary objective is to determine whether the addition of either adjuvant reduces postoperative opioid consumption compared with ropivacaine alone and to assess potential differences in analgesic efficacy between the two adjuvants. Secondary outcomes include p

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age โ‰ฅ 65 years * Scheduled for primary unilateral total knee arthroplasty under standardized anesthetic protocol * ASA physical status II-III (or I-III, zaleลผnie jak planujesz) * Ability to understand the study procedures and provide written informed consent Exclusion Criteria: * Contraindications to peripheral nerve blocks (infection at injection site, coagulopathy, patient refusal) * Known allergy or hypersensitivity to amide local anesthetics, dexamethasone or dexmedetomidine * Chronic opioid therapy or opioid use \> 30 mg oral morphine equivalents per day in the last 3 months * Severe hepatic or renal impairment * Significant cognitive impairment, inability to cooperate with pain assessment * Participation in another interventional trial affecting pain or analgesic consumption
๐Ÿ’Š

What it tests

  • Ropivacaine 0.2% Injectable Solution
  • Dexamethasone 4mg
  • Dexmedetomidine
๐Ÿ“

Where

1 site
Poznan University of Medical Sciences
Poznan, Poland
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy