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The Effect of Vitamin C Supplementation on Gut Microbiota Composition and Function in Healthy Adults

RecruitingNAAges 18 Years - 65 YearsAllUniversity of Glasgow
NCT07388121 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this dietary intervention study is to explore how vitamin C affects the bacteria that live in our gut. Vitamins are essential nutrients found in fruits and vegetables. Our bodies cannot make them on their own, but we need them to function correctly. Vitamins play various roles, including supporting the immune system and assisting with energy production. Some vitamins in our diet can reach the large intestine, where they may be used by gut bacteria to promote their growth. In this study, we aim to investigate how our gut bacteria interact with vitamin C and how this interaction affects their growth and activity. For this study, participants will follow their habitual diet for one-week (run-in period), followed by two consecutive two-week supplementation periods in which they will first take a moderate dose (200 mg/day) and then a high-dose (1000 mg/day) of vitamin C. A final o

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy individuals aged 18-65 years with a BMI between 18.5-35 Kg/m2 * Self-reported good health with no chronic conditions requiring regular medical care * Willing to provide blood, urine, and stool samples at multiple time points Exclusion Criteria: * Aged \<18 or \>65 years * Smoking * Chronic illness requiring regular medication or GP visits * Current or recent medication affecting gut transit or digestion * Major gastrointestinal surgery * Pregnant or breastfeeding * Regular use of pre/probiotics, vitamins, or minerals (unless willing to discontinue 2-4 weeks prior) * Antibiotics in past 3 months * Weight change \>±2 kg in past month * Participation in other research likely to interfere with this study
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What it tests

  • Moderate Vitamin C dose (200 mg)
  • High-dose vitamin C supplementation (1000 mg)
  • Habitual diet (run in period)
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Where

1 site
New Lister Building, Glasgow Royal Infirmary, 10-16 Alexandra Parade, G31 2ER
Glasgow, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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