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โ† Trials
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Diagnostic Accuracy of ECG-less Gated Cardiac CT in Resuscitated Cardiac Arrest Survivors Without ST Elevation Myocardial Infarction

RecruitingNAAges 18 Years - anyAllUniversitair Ziekenhuis Brussel
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In plain words

What the trial is, and whether it could suit you

In a significant portion of patients surviving a cardiac arrest, the event is caused by a myocardial infarction (a narrowing or blockage of one or more blood vessels that supply blood to the heart, the coronary arteries). In some people, this is immediately evident from basic tests; in others, it is more difficult to predict with the currently available tests whether this (or something else) caused the cardiac arrest. We investigate a technique that allows us to also assess the coronary arteries on the CT scan that is performed in patients surviving a cardiac arrest. The coronary angiography is currently the best exam we have for examining the coronary arteries, but it has some disadvantages. Compared to the CT scan, it takes more time, needs a more complex access to the blood vessels, and has some rare but relevant possible complications. The major advantage of the coronary angiography

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๐Ÿ“‹ Eligibility rules (as published)
* Inclusion: * Adults (โ‰ฅ18 years) with sustained return of spontaneous circulation (ROSC) following in/out-of-hospital cardiac arrest. * Informed consent from patient or representative obtained before invasive coronary angiography. * Exclusion * Patients on VA-ECMO * ACS STEMI or STEMI "equivalent" * New left/right bundle branch block * ST segment depression in leads V1-V3, when the terminal T wave is positive and concomitant ST-segment elevation โ‰ฅ 0,5mm recorded in leads V7-V9 (posterior MI) * ST-segment elevation in V7-V9 (posterior MI) or V3R-V4R (RV MI) * ACS NSTEMI with persistent ST depression despite optimal therapy, suggesting ongoing myocardial ischemia, with indication for an urgent ICA according to the treating physician. * Hemodynamic/electrical instability precluding CT imaging (as perceived by the treating physician) * Life-threatening arrhythmia potentially caused by acute myocardial ischemia * Absolute contraindications to iodinated contrast * Patients with a known non-cardiac cause of cardiac arrest (e.g., traumatic brain injury, overt hemorrhage, asphyxia/severe hypoxia due to known lung disease, trauma, severe metabolic/electrolyte derangement, or intoxication) as perceived by the treating physician, where chest CT is considered unnecessary. * Known or likely pregnancy or lactation * Severe bleeding issue (as perceived by the treating physician) precluding heparin administration during radial access coronary angiography. * Prior coronary intervention (stent implantation/CABG). * CT findings indicating a condition that precludes coronary angiography in the short term. * Patients with end-of-life care pathways. * Participation in another intervention study interfering with the research questions in OPEN CCT Arrest.
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What it tests

  • ECG-less gated cardiac CT
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Where

1 site
Universitair Ziekenhuis Brussel (UZB)
Brussels, Belgium
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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