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Natural History, Evolution, and Clinical Features of Autoimmune Atrophic Gastritis

Recruitingn/aAges 18 Years - anyAllFondazione IRCCS Policlinico San Matteo di Pavia
NCT07388459 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Autoimmune atrophic gastritis (AAG) is an immune-mediated disorder characterized by the loss of oxyntic glands and mucosal atrophy1.Specific autoantibodies directed to gastric parietal cells (PCA) and/or to intrinsic factors are inconstantly present1.Despite its morbidity, data on the epidemiology are scant. Its global prevalence has been estimated to be 0.5-4.5%.Hypo-achlorhydria and lack of intrinsic factor lead to malabsorption of many nutrients, as vit. B12, iron and calcium.A damage on elevated turnover cells may develop, affecting hemopoiesis, nervous system, gut, and myocardium, depicting a systemic disease.Moreover, one of the primary function of gastric acidity as a bactericidal defensive barrier is impaired resulting in both gastric and intestinal microbiota modification. It was recently shown that conditions causing hypo-achlorhydria modify the composition of microbiota from s

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male or female, age ≥18 years; * AAG diagnosis is made according to the updated Sydney System criteria referring to a tertiary outpatient clinic dedicated; * Signed written informed consent. Exclusion Criteria: * Patients with uncertain histopathological findings; * Patients with persistent or active Helicobacter pylori infection; * Patients with long-term proton pump inhibitor users and atrophic pangastritis
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What it tests

  • Not listed
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Where

1 site
Fondazione IRCCS Policlinico San Matteo, SC Medicina Generale 1
Pavia, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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