🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy

RecruitingNAAges 8 Years - 17 YearsAllEast Carolina University
NCT07390760 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Remote ischemic conditioning (RIC) is a clinically feasible intervention involving brief, sublethal periods of ischemia followed by reperfusion that has been shown to enhance motor performance, strength, and balance when combined with training in healthy adults and individuals with neurological conditions. Although RIC is thought to influence neuroplasticity through neural, metabolic, and humoral pathways, its effects on spinal-level mechanisms remain poorly understood. Emerging evidence indicates that neuroplastic adaptations occur not only at the cortical level but also within the spinal cord. Moreover, altered spinal reflex excitability is associated with spasticity, balance impairments, and functional limitations in children with cerebral palsy (CP), yet the role of spinal reflex modulations in response to RIC and balance training remains under expplored in this population. Therefore

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Children diagnosed with cerebral palsy (CP) between the ages 8-17 years * Gross motor function classification system levels I-III * Mainstream in school and has sufficient cognition to follow the experiment instructions Exclusion Criteria: * Children with other developmental disabilities such as autism and developmental coordination disorders * Children with cognitive deficits such as inability to understand and follow commands, substantially lower performance at grade level in school, and/or communication problems * Children with balance disorders such as vestibular disorders, posterior fossa tumor etc. * Children with known cardiorespiratory dysfunctions * Children with sickle cell disease * Children who are receiving other adjunct therapies such as transcranial magnetic stimulation, transcranial direct current stimulation, or vagal nerve stimulation * Presence of lower extremity condition, injury, or surgery within last three months which could compromise conditioning and training. * Participants who are pregnant.
💊

What it tests

  • Remote Ischemic Condtioning (RIC)
  • Sham conditioning
  • Balance training
📍

Where

1 site
East Carolina University
Greenville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy