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Electroacupuncture for Generalized Anxiety Disorder: Clinical Efficacy and Neuroimaging Mechanisms

RecruitingNAAges 18 Years - 60 YearsAllLishu Gao
NCT07392645 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to evaluate the clinical efficacy and safety of electroacupuncture (EA) as an adjunctive treatment for generalized anxiety disorder (GAD). Participants in the clinical trial will be randomly assigned to an EA group, a sham EA group, or a waiting-list control group. All participants in the clinical trial will receive monotherapy with one of three SSRIs: sertraline, paroxetine, or escitalopram, selected by a psychiatrist according to clinical suitability, previous treatment response, and tolerability. Clinical efficacy will be assessed using the Hamilton Anxiety Rating Scale (HAMA). The neuroimaging substudy will include healthy controls and two groups of patients with GAD receiving SSRI monotherapy with an unchanged medication type and daily dose for at least 2 weeks: an EA group and a sham EA group. Healthy controls will undergo a single resting-state functional MRI (rs-f

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📋 Eligibility rules (as published)
Inclusion Criteria: * Meet the DSM-5 diagnostic criteria for Generalized Anxiety Disorder (GAD). * the patient has been taking the same anxiolytic medication consistently for 2 weeks prior to enrollment. * HAMA score ≥ 14. * Right-handed（for MRI). * Aged 18-60 years, with at least primary school education. * Signed informed consent. Exclusion Criteria: * Complicated with severe cardiovascular, cerebrovascular, or organic diseases. * History of other psychiatric disorders (e.g., schizophrenia, bipolar disorder). * Contraindications for MRI (e.g., metal implants, claustrophobia). * Pregnancy or lactation.
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What it tests

  • Electroacupuncture (EA)
  • Sham Electroacupuncture (SEA)
  • Medication
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Where

1 site
Affiliated Hangzhou First People's Hospital
Hangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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