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Markers of Bone Destruction and Oxidative Stress in Peri-implantitis

Recruitingn/aAges 18 Years - 65 YearsAllSaglik Bilimleri Universitesi
NCT07397884 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant sulcular fluid (PISF) of patients with peri-implantitis, periodontitis, and healthy individuals. The study seeks to determine the diagnostic value of these biomarkers in the early detection and progression of peri-implant diseases.

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📋 Eligibility rules (as published)
Inclusion Criteria: Systemically healthy volunteers aged 18-65. For Peri-implantitis group: Implants in function for ≥1 year, radiographic bone loss ≥ 2 mm, probing depth (PD) ≥ 5 mm, and presence of bleeding on probing (BOP) or suppuration. For Periodontitis group: At least one tooth with PD ≥ 4 mm, presence of BOP, and radiographic bone loss.For Healthy groups: PD ≤ 3 mm, no clinical inflammation (BOP-), and no radiographic bone loss. (According to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases) - Exclusion Criteria:Presence of systemic diseases (e.g., diabetes, rheumatoid arthritis, osteoporosis). Use of antibiotics, anti-inflammatory, or immunosuppressive drugs within the last 3 months. Pregnancy or breastfeeding. Smoking (current smokers). History of periodontal or peri-implant surgical treatment within the last 6 months. Implant failure (mobility). Signs of acute infection (fever, systemic symptoms). \-
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What it tests

  • Not listed
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Where

1 site
Gülhane Faculty of Dentistry, University of Health Sciences
Keçiören, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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