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โ† Trials
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Gastric Content in Fasting Volunteers and in Tirzepatide Users: an Observational and Cross-sectional Study

Recruitingn/aAges 18 Years - anyAllHospital Israelita Albert Einstein
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In plain words

What the trial is, and whether it could suit you

Introduction Obesity and type 2 diabetes mellitus constitute a global public health problem. Medications with glucagon-like peptide-1 (GLP-1) receptor agonist activity are a modern therapeutic option for both diseases. Liraglutide, semaglutide, dulaglutide and tirzepatide are representatives of this drug class, whose mechanism of action results in delayed gastric emptying, reduced gastric motility and increased gastric volume. Tirzepatide, however, presents a dual agonist action, combining GLP-1 agonism with glucose-dependent insulinotropic polypeptide (GIP) agonism. The presence of gastric content during anaesthesia may lead to pulmonary aspiration and the development of chemical pneumonitis, a potentially devastating complication. However, when there is a risk factor for delayed gastric emptying, despite adequate fasting, the stomach may still present residual content, and bedside u

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18 years or older. * Individuals currently using tirzepatide. * Individuals fasting for at least 8 hours for solids and 2 hours for clear liquids without residue. Exclusion Criteria: * Pregnant or postpartum individuals. * Technical limitation for gastric ultrasound assessment. * Presence of risk factors for gastroparesis. * Use of prokinetic medications such as bromopride, metoclopramide or domperidone.
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What it tests

  • Ultrasonographic evaluation of gastric content
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Where

1 site
Hospital Israelita Albert Einstein
Sรฃo Paulo, Brazil
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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