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Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo

RecruitingEARLY Phase 1Ages 4 Years - 70 YearsAllCombined Military Hospital (CMH) institute of Med…
NCT07398807 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn how well 5 fluorouracil (5FU) with micro-needling works to treat limited vitiligo as compared to strong steroid applied on skin. It will also learn about the safety of both these treatments. The main questions it aims to answer are: * How well does 5FU with microneedling work to treat vitiligo by returning pigmentation in vitiligo patches as compared to steroid? * What is participant's satisfaction when treated with 5FU with microneedling as compared to steroid? * What skin problems do participants have when treated with FU with microneedling and steroid? Researchers will compare 5FU with microneedling to steroid application to see how well both work to return pigment in vitiligo patches. Participants will be divided into two groups. For Group A, 5 FU will be rubbed and absorbed on the vitiligo patch after micro-needling every 2 weeks. For

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients willing to participate in the study * Patients of age group of 05 -70 years. * Vitiligo involving less than or equal to 10% body surface area. Exclusion Criteria: * Patients using or have used other treatments for vitiligo * Pregnant women or lactating women * Patients with unstable vitiligo * Patients on immunosuppressant medications due to other diseases * Patients having anemia, immunosuppression, bleeding disorder, taking anticoagulants or anti-platelet drugs or having epilepsy * Patient having history of keloids or hypertrophic scars * Patients with history of hypersensitivity to either of the drugs
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What it tests

  • Microneedling with 5-fluorouracil
  • Topical application of 0.05% Clobetasol propionate
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Where

1 site
CMH Bahawalpur
Chak Four Hundred Fifty-four, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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