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Differences in N-CAD Concentration and Brain Function Between Children With ASD and TD

Recruitingn/aAges 3 Years - 5 YearsAllChen Li
NCT07400484 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The incidence of autism spectrum disorders is increasing, about 1 / 36. Neural cadherin (NCAD) is closely related to synaptic structure and function. The cdh2 gene encoding NCAD has been shown to be associated with a variety of neurodevelopmental diseases and is one of the six risk genes for ASD. Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technology that uses the principle of near-infrared spectroscopy to detect the functional activation of human cortex. The application of fNIRS to explore the neural mechanism of children with ASD has developed rapidly. It has the advantages of non-invasive, portable, relatively low cost and unlimited physical activity. And for ASD children, their command compliance and self-control are relatively low, so fNIRS is more widely used in ASD children. According to dsm-5 standard, we recruited ASD children and TD children, collected their

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age at enrollment ≥ 3 years and \<5 years; 2. The diagnosis was made by 2 developmental behavioral pediatricians or child psychiatrists with vice senior titles or above, and the history and clinical manifestations were in line with ASD and ICD-11 diagnostic criteria for ASD; . Exclusion Criteria: 1. Diagnosis or manifestation of genetic diseases or syndromes related to ASD (such as Rett syndrome); 2. Medical or nervous system diseases affecting growth, development or cognition (such as central nervous system infection, epilepsy, congenital heart disease, etc.); 3. Sensory impairment such as vision or hearing loss; 4. Low birth weight (birth weight \<2000 g) or preterm birth (gestational age \<37 weeks); 5. Adopted children; 6. Parents refused to sign the informed consent form; 7. Other researchers consider it inappropriate to participate in the study.
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What it tests

  • Not listed
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Where

1 site
Growth, Development and Mental health of Children and Adolescence Center
Chongqing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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