Postoperative Radiotherapy for Early-stage Oral Tongue Squamous Cell Carcinoma Patients With Risk Factors: a Prospective, Multicenter, Randomized Controlled, Open-labelled Trial

Inclusion Criteria: 1. Age ≥ 18 years old and ≤ 70 years old, gender not limited; 2. Newly treated patients (who have not undergone radiotherapy, chemotherapy, or targeted therapy before); 3. Complete resection of the tumor with naked eye and no residual tumor observed in postoperative pathology; 4. The lesion is limited to the anterior 2/3 of the tongue (active part of the tongue); 5. Postoperative pathological diagnosis was squamous cell carcinoma of the tongue; 6. According to AJCC 8th edition, the pathological TNM staging is T1-2N0M0; 7. Having at least one risk factor: vascular cancer thrombus, nerve invasion, moderate or low differentiation; 8. The general status score of the Eastern Cancer Collaboration Group (ECOG) is 0-2 points; 9. Not participating in other clinical trials within the previous 4 weeks prior to screening; If other trials fail to screen cases, but meet the requirements of this trial, they can be enrolled. Exclusion Criteria: 1. Patients who invade the oropharynx, mouth floor, cheeks, neck, and other organs; 2. Have received chemotherapy or other anti-tumor drugs; 3. Previously received radiation therapy for the head and neck area; 4. Patients with active autoimmune diseases that require systemic treatment in the past; 5. Pregnant or lactating women; 6. Individuals with acute infections that are difficult to control; 7. Patients with drug abuse, drug abuse, long-term alcoholism and AIDS; 8. The subjects also have other known invasive malignant tumors (excluding those with no evidence of tumor recurrence through treatment and a duration of more than 2 years); 9. Researchers believe that there are other conditions that hinder patients from participating in this trial.