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Diagnostic Accuracy of Oral Images, OPGs, Biomarkers and Questionnaires vs. Clinical Assessment for Periodontal Disease (PostNCT07164573)

Recruitingn/aAges 18 Years - anyAllShanghai Ninth People's Hospital Affiliated to Sh…
NCT07406867 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This multi-center, cross-sectional diagnostic trial evaluates the accuracy of multiple non-invasive screening tools-including self-reported questionnaires, intra-oral photographs, orthopantomographs (OPGs), intraoral scans (IOS), and salivary/microbial biomarkers-for detecting periodontal health and diseases (gingivitis and periodontitis Stages I-IV), using full-mouth clinical periodontal examination as the reference standard. A total of 2,000 participants will be recruited across five international centers. Diagnostic performance (sensitivity, specificity, AUROC) of individual and combined methods will be assessed using logistic regression and machine learning algorithms to establish an optimized multi-modal screening algorithm.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients aged 18 years or older. * Seeking dental care at one of the participating study centers. * Ability to understand and willingness to provide written informed consent. Exclusion Criteria: * Edentulous patients (complete tooth loss). * Pregnancy or lactation. * History of periodontal therapy (other than supragingival prophylaxis/cleaning) within the past 12 months. * Use of antibiotic medication within the 3 months prior to enrollment.
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What it tests

  • Not listed
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Where

3 sites
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China
Department of Oral and Maxillofacial Sciences, Policlinico Umberto I, affiliated to Sapienza University
Roma, Italy
Department of Periodontology, Guy's Hospital affiliated to King's College London
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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