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IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols

RecruitingNAAges 20 Years - 45 YearsFemaleHanoi Medical University
NCT07409493 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to compare two ovarian stimulation protocols used in in vitro fertilization (IVF): the fixed Progestin-Primed Ovarian Stimulation (PPOS) protocol and the GnRH Antagonist protocol. The study will evaluate IVF outcomes and embryo development patterns using time-lapse embryo monitoring technology. The main questions the study aims to answer are: * Does the fixed - PPOS protocol achieve similar numbers of mature eggs, good-quality embryos, and clinical outcomes compared to the GnRH Antagonist protocol? * Are there differences in embryo development patterns (morphokinetics) between the two protocols when monitored by time-lapse imaging? * How does embryo quality (KIDScore) compare between the two protocols? Study Design: Researchers will randomly assign 148 women undergoing IVF to two groups: * PPOS group (n=74): Will receive FSH injections (oral Duphast

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women aged 20-45 years * Indicated for in vitro fertilization (IVF) treatment * Planned freeze-all embryo strategy * Voluntary participation in research. Exclusion Criteria: * Systemic diseases * Use of hormonal medications within 3 months prior to enrollment * Oocyte donation cycles * Unwilling or unable to participate in research
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What it tests

  • Progestin-Primed Ovarian Stimulation
  • Antagonist protocol for IVF
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Where

1 site
Hanoi Obstetrics and Gynecology Hospital
Hanoi, Vietnam
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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