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International Registry of Dengue Infection in Congenital Bleeding Disorders (DengueCBDR)

Recruitingn/aAges any - anyAllMahidol University
NCT07409857 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Dengue fever, a viral infection transmitted by Aedes mosquitoes, is a major health issue in tropical and subtropical regions. Around 20-30% of symptomatic patients developed Dengue Hemorrhagic Fever (DHF), which leads to impaired hemostasis, subsequently increasing the risk of bleeding. The hemostatic abnormalities associated with dengue infection included vascular permeability, platelet dysfunction, and coagulation defects. Therefore, Individuals with underlying bleeding disorders are at increased risk of bleeding. Dengue infection in patients with hemophilia was reported, including six of 843 patients in the cohort with underlying hemophilia: five with hemophilia A and one with hemophilia B. Replacement therapy was more commonly used in patients with bleeding disorders and dengue than in patients with other febrile illnesses. All of them had bleeding during dengue infection. The morta

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📋 Eligibility rules (as published)
Inclusion Criteria: Patients, aged ≥ 1 day old, diagnosed with CBDs (e.g., hemophilia, von Willebrand disease, and other coagulation factor deficiency) who are diagnosed with dengue infection, based on WHO criteria as follow; Clinical dengue infection: Symptoms of high sustained fever for 3-7 days with 2 of the following: headache, retroorbital pain, myalgia, arthralgia/bone pain, hemorrhagic manifestation, positive tourniquet test, leukopenia (WBC ≤5000/uL) Probable dengue infection: Positive dengue IgM Definite dengue infection: Seroconversion of dengue IgM between acute and convalescent serum OR Rising of dengue IgG (HAI) at least 4 folds between acute and convalescent serum OR Positive NS1 Ag or other dengue-specific antigen tests Dengue hemorrhagic fever: Dengue infection with signs of bleeding (including positive tourniquet test) with platelet count \< 100,000/uL and with signs of leakage (one of the following): 1. Increase Hct at least 15-20% from baseline 2. Serum albumin \< 35 g/L 3. Presence of pleural effusion or ascites Dengue shock syndrome: 1. Narrow pulse pressure (\< 20 mmHg) 2. Hypotension 3. Signs of poor tissue perfusion Severity of DHF: * Grade I: Positive tourniquet test * Grade II: Spontaneous bleeding * Grade III: Circulatory failure (narrow pulse pressure ≤20 mmHg, hypotension, or signs of poor tissue perfusion) * Grade IV: Profound shock with undetectable blood pressure Exclusion Criteria: * Patients with CBDs with dengue infection who are not willing to participate in the study
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What it tests

  • Not listed
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Where

1 site
Ramathibodi Hospital
Bangkok, Thailand
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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