💬In plain words
What the trial is, and whether it could suit you
This randomized controlled trial aims to compare the anesthetic efficacy of 2% lignocaine administered through an inferior alveolar nerve block (IANB) in one group of participants with 4% articaine delivered via primary buccal infiltration in other group in patients with symptomatic irreversible pulpitis in mandibular first molars.
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
* Systemically healthy patients classified as ASA I, aged 18-55 years.
* Permanent mandibular first molar tooth requiring endodontic therapy.
* Diagnosed with symptomatic irreversible pulpitis without swelling or sinus.
* Normal periapical radiographic appearance (no evidence of periapical pathology).
* Moderate pain as assessed by the Heft-Parker VAS (\>54 mm and \<114 mm).
* Lingering pain or prolonged response to cold testing (lasting more than 10 seconds).
* Positive response to electric pulp testing.
* Outcome assessed must be pulpal anesthesia
Exclusion Criteria:
* • Pregnant or lactating mothers.
* Teeth with reversible pulpitis, previously treated, or with calcified canals.
* Teeth with severe periodontal disease or periapical radiolucency.
* Patients who have taken analgesics or anti-inflammatory drugs within 6 hours before the treatment visit.
* Patients on medications that could potentially interact with the anesthetic solution (e.g., antihypertensives, anticoagulants).
* History of allergy to 4% articaine, lidocaine, or epinephrine.
* Systemic diseases, immunocompromised states, or significant anxiety/mental health disorders.
* History of vasovagal syncope on local anesthetic administration
💊
What it tests
- INTERVENTION 1: 2% Lignocaine 1:80,000 epinephrine
- INTERVENTION 2 : 4%Articaine 1:100,000 epinephrine
Armed Forces Institute of Dentistry AFID CMH Rawalpindi
Rawalpindi, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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