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Correlating EEG Dynamics With Consciousness Alteration Under Anesthesia

Recruitingn/aAges 18 Years - 80 YearsAllHuazhong University of Science and Technology
NCT07410702 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective observational study is designed to investigate and compare the dynamic features of whole-brain electroencephalogram (EEG) during the induction of unconsciousness using various anesthetic agents with distinct pharmacological mechanisms. The primary objective is to identify common, drug-agnostic EEG biomarkers of anesthetic depth and to develop a novel, universal assessment system that addresses the limitations of the currently prevalent Bispectral Index (BIS), which demonstrates variable sensitivity across different anesthetics. Approximately 250 adult patients (ASA I-II) scheduled for elective surgery under general anesthesia will be enrolled. Patients will undergo preoperative cognitive assessment prior to induction. During anesthesia induction, 32-channel EEG signals will be continuously recorded alongside BIS values and behavioral state assessments using the MOAA/S s

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥ 18 years. 2. Scheduled to undergo elective surgery requiring general anesthesia with endotracheal intubation or laryngeal mask airway (LMA). 3. American Society of Anesthesiologists (ASA) Physical Status Class I to III. 4. Preoperative Mini-Mental State Examination (MMSE) score ≥ 24, indicating normal cognitive function. 5. Body mass index (BMI) ≤ 30 kg/m². 6. Ability to understand the study and provide written informed consent. Exclusion Criteria: 1. History of drug abuse or dependence. 2. Known major neurological disorders (e.g., epilepsy, stroke, neurodegenerative diseases). 3. History of major psychiatric disorders. 4. Known or suspected pregnancy. 5. Inability to provide informed consent due to cognitive impairment, language barrier, or any other reason.
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What it tests

  • Anesthetic Agents
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Where

1 site
Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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