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Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With "Classic" Polycystic Ovary Syndrome (PCOS)

RecruitingNAAges 18 Years - 45 YearsFemaleAssistance Publique - Hôpitaux de Paris
NCT07412028 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Diagnostic case-control study (1 case for 2 controls). Inclusion of patients with severe insulin resistance syndrome of genetic origin, then inclusion of controls: patients examined for PCOS in day hospital with matching age (+/- 5 years) and Body mass index (+/- 5kg/m2).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women aged ≥ 18 years and \< 45 years ; * Discontinuation of estrogen-progestin therapyfor at least 3 months ; * Signed informed consent ; * Social security affiliation. Case (n=25): \- Patient with a lipodystrophic syndrome due to a known pathogenic variant of the LMNA gene. Control (n=50), : \- patient consulting for polycystic ovary syndrome (PCOS according to the Rotterdam criteria) in day hospital matched on age +/-5 years and BMI+/-5 kg/m2. Exclusion Criteria: * \- Severe renal insufficiency (GFR \< 30 ml/min) ; * Hepato-cellular insufficiency (TP \< 50%) ; * Taking corticosteroids or antiretrovirals ; * Menopausal women ; * Taking estrogen-progestin therapy; * Diabetic patients on insulin : type 1 diabetes or pancreatectomised patients * Other known causes of hyperandrogenism (21-hydroxylase block, Cushing's syndrome, ovarian tumor). * Pregnant woman * Breastfeeding woman
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What it tests

  • Genetic analysis
  • Biological analysis
  • imaging test
  • Standard intervention
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Where

1 site
Service Endocrinologie, Hôpital St Antoine
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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