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Continued Pressure for Alveolar Protection (CPAP Trial)

RecruitingNAAges any - 31 WeeksAllNICHD Neonatal Research Network
NCT07417111 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The objective of the CPAP Trial is to test whether extending CPAP until 34 weeks' PMA or for at least 2 additional weeks compared to weaning to a nasal canula will decrease the likelihood of bronchopulmonary dysplasia or death at 36 weeks' PMA.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Gestational age \<29 weeks at birth * PMA \<32 weeks at study entry * On treatment with CPAP without a rate in FiO2 \<0.25 and PEEP of 4-5 cmH2O * Meet stability criteria: * If previously intubated must be extubated ≥ 72 hours * \<3 self-resolving apneas (≤ 20 s) and/or bradycardia (\<100 bpm) in any hour over previous 6 hours * No episodes of apnea or bradycardia requiring intervention (oxygen/stimulation/bag and mask) for 24 hours * Parents/legal guardians consent for enrollment Exclusion Criteria: * Major malformation * Neuromuscular condition that affects respiration * Terminal illness * Decision to withhold or limit support * Too sick to participate in opinion of Attending physician * Clinical shock, sepsis * Planned surgery during study period
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What it tests

  • CPAP
  • Nasal Cannula
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Where

15 sites
University of Alabama at Birmingham
Birmingham, United States
Stanford University
Palo Alto, United States
Sharp Mary Birch Hospital for Women & Newborns
San Diego, United States
Emory University
Atlanta, United States
Northwestern Lurie Children's Hospital of Chicago
Chicago, United States
University of Iowa
Iowa City, United States
University of Mississippi Medical Center - Children's of Mississippi
Jackson, United States
University of New Mexico
Albuquerque, United States

…and 7 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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