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"Effect of Albumin Combined With Furosemide in Critically Ill Patients With Fluid Overload: Impact on Urine Output and Renal Function"

RecruitingNAAges 18 Years - 100 YearsAllJose J Zaragoza, MD MSc
NCT07417969 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to compare the effectiveness of furosemide alone versus the combination of furosemide plus albumin in critically ill adult patients with fluid overload. The trial evaluates whether co-administration of albumin enhances diuretic response compared with standard furosemide therapy. The primary outcomes include urine output at 2 hours, changes in renal perfusion markers, and biochemical parameters. Secondary outcomes include changes in mean arterial pressure, electrolyte balance, and renal resistance index. The study seeks to determine whether adding albumin provides a clinically meaningful improvement in diuresis and renal function compared with furosemide monotherapy.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults ≥18 years * Critically ill patients admitted to the intensive care unit (ICU) * Presence of oliguria defined as urine output \<0.5 mL/kg/hour for at least 6 hours Exclusion Criteria: * Refusal to participate by the patient or legal representative * Patients receiving palliative or end-of-life care * Acute or chronic kidney failure requiring ongoing renal replacement therapy at enrollment * Chronic dialysis dependency * Participation in another interventional clinical trial * Pregnant or lactating women
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What it tests

  • Furosemide plus albumin
  • Furosemide (Diuretic)
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Where

1 site
76000
Querétaro City, Mexico
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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