💬In plain words
What the trial is, and whether it could suit you
Allergy to Cow's milk and hen´s egg proteins are the most common causes of food allergies in early childhood and are associated with the occurrence of adverse events that may be life-threatening, quality of life impairment and negative nutritional and health economic impact.
However, contrarily to other food allergy models such as nuts/peanut allergy, milk and egg allergy have greater chances of natural resolution. While around 50% of children may outgrow milk or egg allergy by the age of 5 years old, only 22% of peanut allergic children at the age of 4 years can tolerate this food. However, it is also documented that, at 14 years of age, the persistence of milk and egg allergy still affects around 30% of these children.
Standard of care relies on food avoidance and treatment of accidental reactions, but this approach is unsatisfactory because adverse events and quality of life limitat
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
NAT-cohort:
* Cow´s Milk and/or Hen´s Egg allergic patients 4 to 10 years old
* sIgE levels to milk OR egg extracts between 0.35 to 35kUA/L
* Positive entry Open food challenge with milk/egg with oFASS5 classification ≥2 with a maximum cumulative dose of up to 4193.7 mg of milk protein or 3110.8 mg of egg white protein
* Having a mild to moderate food allergy severity per the Definition of Food Allergy Severity (DEFASE) score (\<13 points)
* Having signed the informed consent
OIT-cohort:
* Patients in the compITO study (NCT06976775) who are undergoing OIT and have achieved full desensitization to the food by month 7 of the study (end of study)
* Patients in the compITO study who are undergoing OIT and have achieved partial desensitization (tolerating a dose lower than the total dose, and a minimum of 3 doses above the entry challenge threshold) to the food by month 7 of the study (end of study)
* Having signed the informed consent
Exclusion Criteria:
NAT-cohort:
* Positive reaction in the entry open oral food challenge with a baseline Eliciting Dose (ED) 20 below the target ED20 for food. For milk, 23.1 mg (35.7 mg cumulative) of protein, or for egg, 19.5 mg (29.4 mg cumulative) of protein.
* Patient desire or medical indication to initiate OIT at any time within 29 months of study entry.
* No allergic reaction greater than oFASS5 grade 1 in the baseline challenge for the maximum cumulative programmed doses of 4193.7 mg of milk protein, or 3110.8 mg of egg white protein.
* Immunological diseases, immunomodulatory/blocking therapies.
* Severe atopic dermatitis according to the SCORing Atopic Dermatitis (SCORAD) classification
* Severe allergy, according to a DEFASE score ≥13
* Spirometry values with moderate-to-severe airflow obstruction (FEV1 \<70%)
* Poorly controlled asthma according to clinical criteria
* Previous OIT for another food
* Within the first 3 months of treatment with Subcutaneous Aeroallergen Immunotherapy
* Within the first week of treatment with Sublingual Aeroallergen Immunotherapy
* Presence or suspicion of Eosinophilic Esophagitis
* Non-IgE-mediated allergy to milk or egg
* Pregnancy
* Significant medical comorbidities (renal, hepatic, or cardiac insufficiency, active infectious diseases, previous or concurrent cancers)
* Inability to provide informed consent
* Communication or cognitive barriers that prevent adherence to the protocol
OIT-cohort:
* Patients enrolled in the compITO study who have failed or withdrawn from the study for any reason.
* Patients with uncontrolled Atopic Dermatitis or Asthma at the time of enrolment, or who have developed Eosinophilic Esophagitis.
* Patients with confirmed pregnancy at the time of enrolment.
* Patients who have developed significant medical comorbidities (renal, hepatic, or cardiac insufficiency, active infectious diseases, previous or concurrent cancers) at the time of enrolment.
* Inability to provide informed consent.
* Communication or cognitive barriers that prevent adherence to the protocol.
💊
What it tests
- Oral Immunotherapy
- Allergenic food avoidance
Hospital Infantil Universitario Niño Jesús. Avenida de Menéndez Pelayo, número 65
Madrid, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
HealthTeky