💬In plain words
What the trial is, and whether it could suit you
Individuals diagnosed with schizophrenia and related psychotic disorders (SZ) exhibit a markedly elevated risk of premature mortality, with a 10-20-year shorter lifespan relative to the general population. Increased mortality rates in SZ are largely attributable to the early manifestation of medical conditions that normally occur later in life, a process known as 'accelerated aging'. While unhealthy lifestyle behaviors, such as smoking and unhealthy diet, account, in part, for accelerated aging in SZ, the excess of physical comorbidities cannot be solely attributed to these factors. Remarkably, the direct adverse health effects of key clinical characteristics of SZ have rarely been considered. In the general population, the absence of social contact is known to pose enormous challenges for physical health, especially at older ages. Given that social isolation is a persistent and disablin
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion and exclusion criteria for participants with SZ:
* DSM-IV or V diagnosis of a SZ related disorder (295.x, 297.1, 298.8, or 298.9; e.g., schizophrenia, schizoaffective disorder, schizophreniform disorder, but not psychotic disorder that is solely substance induced) based on clinical interview;
* Between 40 and 70 years of age at time of study recruitment;
* Participant was enrolled in a previous research study between the ages of 20-55, and this study took place at least 5 years ago;
* Able to understand the spoken language of the participating country sufficiently to comprehend testing procedures;
* No history of serious head injury (i.e., loss of consciousness longer than 1 hour, no neuropsychological sequelae, no cognitive rehabilitation treatment post head injury);
* No history of IQ \< 70, or developmental disability based on chart review;
* Clinically stable (i.e., no inpatient hospitalizations for three months prior to enrollment, no changes in medication in the four weeks prior to enrollment;
The inclusion and exclusion criteria for sibling participants in this study will be:
* No history of any DSM IV/V Axis I or axis II diagnosis that is known to be associated with social functioning (e.g. severe mood disorder, schizoaffective personality disorder, autism spectrum disorder);
* Between 40 and 70 years of age at time of study recruitment;;
* Participant was enrolled in a previous research study between the ages of 20-55, and this study took place at least 5 years ago;
* Able to understand the spoken language of the participating country sufficiently to comprehend testing procedures;
* No history of serious head injury (i.e., loss of consciousness longer than 1 hour, no neuropsychological sequelae, no cognitive rehabilitation treatment post head injury);
* No history of IQ \< 70, or developmental disability based on chart review;
* Clinically stable (i.e., no inpatient hospitalizations for three months prior to enrollment, no changes in medication in the four weeks prior to enrollment
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