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Real-World NeuroModulate: Investigating Non-Invasive Brain Stimulation for Neuropsychiatric Disorders at TUM

Recruitingn/aAges 18 Years - anyAllTechnical University of Munich
NCT07420322 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In this study, patients diagnosed with a depressive syndrome and with a clinical indication for treatment will receive an acute course of transcranial magnetic stimulation (TMS). The treatment consists of 20 TMS sessions administered over a period of four weeks (five sessions per week). Magnetic resonance imaging (MRI) will be performed at four time points: prior to the start of treatment, after 10 treatment sessions, after completion of all 20 sessions, and at a three-month follow-up after the end of treatment. The MRI data will include different imaging modalities to assess treatment-related neurobiological changes. The primary objective is to investigate changes in neuroimaging markers over the course of TMS treatment and to examine their associations with clinical response and behavioral as well as clinical outcome measures. Another key goal of the study is the identification of ma

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📋 Eligibility rules (as published)
Inclusion Criteria: Age 18 years or older Clinical indication for non-invasive brain stimulation due to a depressive episode (e.g., unipolar or bipolar depression) or predominant depression-associated symptoms (e.g., negative symptoms in schizophrenia-spectrum disorders) Insufficient response to first-line treatments and/or patient preference for brain stimulation treatment Capacity and willingness to provide written informed consent Exclusion Criteria: Acute suicidal risk Presence of a significant neurological disorder or condition, including: Increased intracranial pressure Space-occupying brain lesions History of cerebrovascular accident within the last 12 months Incidental structural brain abnormalities on MRI requiring further diagnostic clarification For TMS specifically: Non-removable ferromagnetic implants in or near the stimulation site (e.g., cochlear implants, implanted neurostimulators, metallic clips or nails) Other treatment-relevant ferromagnetic implants (e.g., cardiac pacemakers)
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What it tests

  • iTBS Treatment
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Where

1 site
University Hospital Technical University of Munich
München, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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