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Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain Syndrome

RecruitingNAAges 18 Years - 65 YearsFemaleCairo University
NCT07421427 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to evaluate the additive effect of Amantadine or Duloxetine to Pregabalin on development of post mastectomy pain syndrome

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age from 18 to 65 years. * American society of anesthesiologists (ASA) Physical status II, III. * Body mass index (BMI): (20-40) kg/m2. * Type of surgery: patients undergoing modified radical mastectomy for breast cancer. Exclusion Criteria: * Patient refusal. * Patients with Known sensitivity or contraindication to drug used in the study. * History of psychological disorders and/or chronic pain and drug abuse patients. * Previous administration of antidepressants, anticonvulsants, or opioids before surgery. * Severe respiratory or cardiac disorders. * Advanced liver or kidney disease. * Previous breast surgery
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What it tests

  • Pregabalin
  • Pregabalin + Amantadine
  • Pregabalin + Duloxetine
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Where

1 site
Cairo University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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