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PlaCEUS: Feasibility Study of Contrast-enhanced Ultrasound to Visualize Maternal Uterine Spiral Arteries Postpartum.

RecruitingNAAges 18 Years - anyFemaleMaxima Medical Center
NCT07422181 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

During pregnancy, unique blood vessels form within the uterine wall, known as spiral arteries. These vessels originate from the uterine artery, which is the main artery supplying blood to the uterus. Throughout pregnancy, spiral arteries undergo significant changes to increase blood and oxygen flow to the placenta, ensuring the developing baby receives adequate nutrients. When these arteries fail to remodel properly, complications such as pre-eclampsia or fetal growth restriction can occur. Until now, direct observation and evaluation of spiral arteries during pregnancy has not been feasible. Contrast-enhanced ultrasound may provide a breakthrough in this area. In this study, the investigators aim to use this imaging technique to visualize spiral arteries after the placenta has been delivered. If successful, this could allow to assess their structural quality. Additionally, the investig

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📋 Eligibility rules (as published)
Inclusion Criteria: * Pregnant patient at a minimum age of 18 years * Singleton pregnancy at term (≥37 weeks gestation) * Planning to deliver at the Máxima Medical Centre * Able to provide informed consent * Intravenous access present at the time of delivery Exclusion Criteria: * Multiple gestation pregnancy * Contra-indications to CEUS, e.g. known allergy for constituents of SonoVue™ * Planning on breastfeeding * Medical emergency during or after delivery, which makes CEUS impossible or undesirable * No intravenous access present at the time of delivery * Body Mass Index \>40 kg/m2. * Pre-eclampsia requiring medication * Foetal growth restriction \< p3
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What it tests

  • SonoVue (sulphur hexafluoride microbubbles)
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Where

1 site
Máxima Medical center
Veldhoven, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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