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Perioperative Outcomes After Neoadjuvant Therapy in Colorectal Cancer

Recruitingn/aAges 18 Years - anyAllOsijek University Hospital
NCT07422974 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective study investigates the effects of neoadjuvant therapy on endothelial function, microvascular tissue density, and tissue fibrosis in patients with colorectal cancer and their association with perioperative complications. The primary objective is to assess differences in microvascular tissue density between patients who received neoadjuvant therapy and those who did not, biomarkers, and demographic factors between patients who received neoadjuvant therapy and those who underwent surgery as initial treatment, and to compare clinical outcomes. The study will include 34 patients treated with neoadjuvant therapy and 34 patients for whom surgery is the first-line treatment. Patients will be followed until discharge from the hospital, and complications after discharge will be monitored through medical records one month after surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged ≥18 years with histologically confirmed colorectal cancer * Planned surgical treatment for colorectal cancer (either laparoscopic LPSC or open laparotomy) * Ability to understand the study protocol and provide written informed consent. * Both sexes * ASA classification II or III * Patients who received neoadjuvant therapy is investigational group and patients who did not receive neoadjuvant therapy is control group Exclusion Criteria: * Age \<18 years * Patients who are not conscious, not oriented, or unable to provide informed consent * Patients unable to understand the study protocol * Emergency surgical cases * Patients on chronic corticosteroid therapy
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What it tests

  • Skin and subcutaneous tissue sampling for histopathological analysis
  • Blood sampling for laboratory analyses before and after surgery
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Where

1 site
KBC Osijek
Osijek, Croatia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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