🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Monitoring Respiratory Muscle Function in Acute Respiratory Failure Patients on Non Invasive Respiratory Support

RecruitingNAAges 18 Years - anyAllQueen Mary University of London
NCT07423338 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Acute respiratory failure is a common, life-threatening condition where the lungs cannot provide enough oxygen to the body. Many patients are treated with non-invasive respiratory support (NRS) such as high-flow nasal oxygen (HFNO), continuous positive airway pressure (CPAP), or bilevel positive airway pressure (BiPAP). However, up to half of patients receiving NRS still deteriorate and require intubation and invasive ventilation, which is linked to longer hospital stays, more complications, and slower recovery. A major challenge in caring for these patients is that clinicians currently cannot directly see how well the breathing muscles (especially the diaphragm and parasternal intercostal muscles) and the lungs are working while the patient is using NRS. Existing bedside measures, such as respiratory rate or oxygen levels, only show part of the picture. They do not indicate how hard th

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Adult (≥18 years old) * with acute respiratory failure with hypoxia (i.e. arterial oxygen tension (PaO2) of \<8.0 kPa), and/or with or without hypercapnia (i.e. arterial carbon dioxide tension (PaCO2) of \>6.0 kPa) from any underlying disease or cause * requiring any non-invasive respiratory support (i.e. HFNO, CPAP, BiPAP) * Multidisciplinary critical care staff involved in the management of those recruited patients with acute respiratory failure requiring non-invasive respiratory supports. Staff will possibly have an interview and are also required to complete a questionnaire. Exclusion Criteria: * Patients in respiratory arrest defined as the total cessation of airflow and breathing effort and absent ventilation (24,25) * Patients requiring immediate intubation * Patients with Glasgow Coma Scale (GCS) \< 8 * Patients with severe facial trauma or burns * Patients with fixed upper airway obstruction or inability to protect the airway * Patients with severe agitation and/or confusion that prevent use of the device mask * Patients with severe vomiting * Pregnancy * Patients with pacemakers and other electronic devices in the thorax * Patients on end-of-life care or palliative care (defined as expected to die and/or not receiving active treatment) * Contra-indication to EIT or ultrasound monitoring (e.g. burns, severe obesity, thoracic wounds limiting instrument placement, and thoracic drain)
💊

What it tests

  • Advanced respiratory monitoring
📍

Where

2 sites
Royal London Hospital
London, United Kingdom
Newham Hospital
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy