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Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)

RecruitingNAAges 18 Years - anyAllAttikon Hospital
NCT07425457 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults ≥18 years undergoing primary TKA for osteoarthritis. * Cognitively normal and able to self-assess pain and function. * Provide written informed consent. Exclusion Criteria: * Cancer-related knee pain. * Neurological, psychiatric, or medical conditions interfering with assessment. * Chronic opioid users.
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What it tests

  • CT-guided Cryoneurolysis of the Genicular Nerves
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Where

1 site
Attikon University General Hospital
Athens, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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