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Impact of Pre-operative Sarcopenia on Functional Recovery After Hip Arthroplasty in Older Adults

RecruitingNAAges 75 Years - anyAllUniversity Hospital, Montpellier
NCT07429955 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This single-centre, exploratory study at Montpellier University Hospital will investigate whether having low muscle mass and strength before hip-replacement surgery, a condition called sarcopenia, impact the return to everyday independence in people aged 75 years or older. About 20 volunteers, scheduled for surgery because of a recent femoral-neck fracture or severe arthritis that no longer responds to usual care, will give consent, answer brief health questionnaires, attempt simple walking and chair-rise tests if possible, and provide a small blood sample. While they are already under anaesthesia for their planned operation, the surgical team will take a tiny muscle sample through the same incision, so no extra cuts are needed. During the hospital stay or shortly after discharge, each participant will have a painless MRI scan of the thigh muscles and a very-low-dose bone scan (DXA) to m

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📋 Eligibility rules (as published)
Inclusion Criteria: \- Elderly subjects undergoing surgical hip replacement for fracture of the upper end of the femur or severe hip osteoarthritis. Exclusion Criteria for both groups : * Contraindications to MRI : pacemaker, metallic implants. * Presence of a lower-limb prosthesis on the contralateral side to the surgery that may interfere with quadriceps mass measurements. * Progressive high-grade neoplasia. * Documented major cognitive disorders * Under legal protection measures (guardianship, conservatorship, or curatorship). * Subjects not affiliated with or not covered by a social security system. * Participation in another ongoing study with an active exclusion period. Exclusion criteria - Fracture group : * Fracture with a suspicion of underlying neoplasia. * Placement of a lower-limb prosthesis on the surgical side within the last 12 months. * Inability to walk with or without human/technical assistance prior to fracture. Exclusion criteria - Hip osteoarthritis group : \- Active inflammatory joint disease (rheumatoid arthritis, spondyloarthritis).
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What it tests

  • Total hip replacement
  • Blood sampling
  • Muscle biopsies
  • Collection of joint samples derived from surgical waste
  • DXA
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Where

1 site
University Hospital
Montpellier, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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