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Effect of Acute Hypoxia on RIght VEntRicular Function in HAPE.

RecruitingNAAges 18 Years - 80 YearsAllMona Lichtblau
NCT07431554 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with past HAPE responds to this stress is still not well understood. Therefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity in patients with past HAPE. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability. In addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The "altitude" i

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📋 Eligibility rules (as published)
Inclusion Criteria: * Signed informed consent * Diagnosed or suspicion of past HAPE * 18-80 years (age group young: 18-39.99 years / age group older: 40-80 years) * All sex and genders * Living \<800m and without altitude exposure \> 2500 m and \> 24h within the last three weeks Exclusion Criteria: * \<18, \>80 years old * Any other diagnosed cardiopulmonary condition * Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.) * Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders * Participants permanently living \>800m and altitude exposure \> 2500 m and \>24h within the last three weeks * Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy * Lactating women * Participation in other study with active treatment
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What it tests

  • Normobaric Hypoxia
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Where

1 site
Consultant Clinic of Pulmonology, University Hospital of Zurich
Zurich, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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