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Single-step vs Stepwise Lung Recruitment Maneuvers After Cardiopulmonary Bypass

RecruitingNAAges 18 Years - 80 YearsAllOndokuz Mayıs University
NCT07432477 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective randomized controlled trial aims to compare the hemodynamic and pulmonary effects of single-step and stepwise lung recruitment maneuvers in adult patients undergoing elective cardiac surgery with cardiopulmonary bypass. After separation from cardiopulmonary bypass, patients will be randomized to receive either a single-step sustained inflation recruitment maneuver or a stepwise incremental recruitment maneuver, both combined with 8 cmH₂O positive end-expiratory pressure. The primary outcome is the change in cardiac index before and after the recruitment maneuver. Secondary outcomes include lung ultrasound atelectasis score, and hemodynamic parameters.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18-80 years * ASA (American Society of Anesthesiologists) II-IV * Patients undergoing elective cardiac surgery (coronary artery bypass grafting, mitral valve replacement, aortic valve replacement) Exclusion Criteria: * Emergency surgery * Presence of perioperative arrhythmia * \<35% left ventricular ejection fraction * \>50 mmHg systolic pulmonary artery pressure * Known chronic obstructive pulmonary disease or interstitial lung disease * Pneumothorax * Mean arterial pressure \<60 mmHg during recruitment maneuver * New York Heart Association (NYHA) class III-IV heart failure * Advanced cardiomyopathy or severe mitral regurgitation * Cross-clamp time longer than 2 hours * Requirement for high-dose inotropic or vasopressor support * Patients who cannot be extubated after postoperative 24 hours
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What it tests

  • Single Step Lung Recruitment Maneuver
  • Stepwise Lung Recruitment Maneuver
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Where

1 site
Ondokuz Mayıs University, Faculty of Medicine
Samsun, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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