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PAravertebral CaTheter Versus Epidural Analgesia in Totally Minimally Invasive Esophagectomies

RecruitingNAAges 18 Years - anyAllUniversity Hospital, Lille
NCT07434739 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Esophageal cancer ranks as the seventh leading cause of cancer globally, with 604,100 new cases, and the sixth leading cause of cancer-related deaths worldwide. When applicable, surgery is the gold standard treatment for resectable oesophageal-esophagogastric junction cancer. The surgical technique requires both an abdominal approach and a transthoracic approach to resect the esophagus, perform the anastomosis, and allow optimal lymph node removal. Surgery Historically, esophagectomy was performed entirely through open surgery. This procedure was complex, associated with significant morbidity and mortality, as well as intense acute and chronic postoperative pain. In this context, thoracic epidural analgesia (TEA) is the gold standard in the management of acute postoperative pain. It allows for opioid sparing and reduces postoperative pulmonary complications. In order to reduce postop

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient requiring totally minimally invasive surgical esophagectomy (robot-assisted or not) with 2 Ivor-Lewis type approaches: laparoscopy for the abdominal approach and thoracoscopy for the thoracic approach. * Age ≥ 18 years old * Patient who has given written consent to participate in the trial * Socially insured patient * Patient willing to comply with all study procedures and duration Exclusion Criteria: * \- Intervention planned by open esophagectomy (laparotomy and/or thoracotomy) * 3-stage esophagectomy, McKeown type * Obesity with body mass index ≥ 35 kg.m-2 (due to the foreseeable difficulties arising from this BMI). * Pregnancy * Haemostasis trouble * ASA score \> 3 * Renal failure (eGFR \< 50 mL/min) * Ongoing opioid use (\>3 months prior to the day of surgery) * Contraindication to local anesthesia * Local infection * Inability to receive informed information * Person deprived of the liberty * Person benefiting from a system of legal protection (guardianship…)
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What it tests

  • paravertebral catheter analgesia
  • Epidural group
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Where

1 site
CHU de Lille
Lille, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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