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Iron Absorption From IFA and MMS Supplements in Kenyan Women During the Second Trimester of Pregnancy

RecruitingNAAges 18 Years - 35 YearsFemaleETH Zurich
NCT07435766 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study evaluates iron absorption from three antenatal supplements, 30 mg MMS, 60 mg MMS, and 60 mg IFA, in 50 pregnant Kenyan women in their second trimester. Using a randomized crossover design and stable iron isotopes, we will compare bioavailability in both fasted and fed states. Additionally, the trial will investigate if daily dosing triggers a hepcidin response that inhibits subsequent absorption, testing whether alternate-day dosing is a more effective strategy for treating iron deficiency.

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📋 Eligibility rules (as published)
Inclusion Criteria: * female * pregnant at gestational age 12 (±1) weeks (dated by ultrasound) * age 18 to 35 y * Hb concentration ≥80 g/L * absence of significant inflammation * body weight \<80 kg * no major chronic diseases * no intake of vitamin and mineral supplements outside of this study in the 1-2 weeks between screening and study start and during the study * no blood transfusion, blood donation, or significant blood loss over the past 4 months Exclusion Criteria: * severe anemia (defined as Hb \<80 g/L) * malaria * sickle cell disease (SS and SC) * hemoglobin C disease (CC).
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What it tests

  • MMS with 30 mg iron
  • MMS with 60 mg iron
  • IFA with 60 mg iron
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Where

2 sites
Kwale Sub County Hospital
Kwale, Kenya
Msambweni County Referral Hospital
Msambweni, Kenya
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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