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F-18 Tetrafluoroborate PET/CT in Differentiated Thyroid Cancer

RecruitingNAAges 18 Years - anyAllAnkara University
NCT07436455 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In patients who have undergone surgery for differentiated thyroid cancer and who demonstrate elevated serum Tg and/or ATg levels during follow-up after radioactive iodine therapy, lesion detection is performed using neck ultrasonography, thorax CT, and F-18 FDG PET/CT. Diagnostic whole-body scanning with low-dose I-131 is not routinely recommended in follow-up due to its low sensitivity and specificity. F-18 TFB is a highly specific imaging agent for differentiated thyroid cancer, entering thyroid follicular epithelial cells via the sodium-iodide symporter (NIS), which is expressed on the cell surface and functions through a mechanism similar to that of I-131. As a PET radiotracer, F-18 TFB has been shown to be superior to I-131 in previous studies. The primary aim of this study is to comparatively evaluate the role of F-18 TFB PET/CT versus the standard imaging modality F-18 Fluorodeo

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📋 Eligibility rules (as published)
Inclusion Criteria: * Having undergone surgery for differentiated thyroid cancer and received radioactive iodine therapy * Being evaluated for lesion detection due to elevated serum Tg and/or ATg levels during post-treatment follow-up * Negative or equivocal I-131 whole-body scan findings * Karnofsky Performance Status ≥ 50 (or equivalent Eastern Cooperative Oncology Group \[ECOG\]/World Health Organization \[WHO\] performance status) * Giving written informed consent Exclusion Criteria: * Age under 18 years * Pregnancy or breastfeeding * Failure to provide written informed consent
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What it tests

  • F-18-Tetrafluoroborate PET/CT
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Where

2 sites
Ankara University Medical School Nuclear Medicine Department
Ankara, Turkey (Türkiye)
Hacettepe University Medical School Nuclear Medicine Department
Ankara, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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